2-ethoxy-4-phenylquinoline

Base Information

• Chemical Name: 2-ethoxy-4-phenylquinoline
• CAS No.: 83463-88-1
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.312
• Mol file: 83463-88-1.mol

Synonyms:2-ethoxy-4-phenylquinoline

Chemical Property of 2-ethoxy-4-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethoxy-4-phenylquinoline

There total 6 articles about 2-ethoxy-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-amino-benzenethiol (137-07-5) + phenylpropynoic acid ethyl ester (2216-94-6) → 2-ethoxy-4-phenylquinoline (83463-88-1)

Guidance literature:

2-amino-benzenethiol; phenylpropynoic acid ethyl ester; With zirconocene dichloride; L-phenylalanine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With iodine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1039/d1ra06976d

Reference yield: 70.0%

1-ethoxyacetylene (927-80-0) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-ethoxy-4-phenylquinoline (83463-88-1)

Guidance literature:

1-ethoxyacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 4.33333h; Inert atmosphere;

(2-aminophenyl)(phenyl)methanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201200782

Reference yield: 64.0%

2-ethoxy-4-hydroxy-4-phenyl-3,4-dihydroquinoline → 2-ethoxy-4-phenylquinoline (83463-88-1)

Guidance literature:

With acetic acid; In ethanol; for 48h; Heating;

upstream raw materials:

2-chloro-4-phenylquinoline

sodium ethanolate

(2-aminophenyl)(phenyl)methanone

N-(2-Benzoyl-phenyl)-acetimidic acid ethyl ester

Downstream raw materials:

4-phenyl-2-quinolinone