4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid

Base Information

• Chemical Name: 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid
• CAS No.: 220717-55-5
• Molecular Formula: C₁₇H₂₂N₂O₅
• Molecular Weight: 334.372
• Mol file: 220717-55-5.mol

Synonyms:4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid

Chemical Property of 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid

There total 4 articles about 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(4S,5R)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (145587-62-8) → 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid (220717-55-5)

Guidance literature:

With sodium hydroxide; In methanol; at 0 ℃; for 1h;

DOI:10.1021/jo981664i

Reference yield:

(4R,5R)-2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (267653-10-1) → 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid (220717-55-5)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/S0040-4020(00)00767-5

Reference yield:

(4S,5S)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (145587-61-7) → 4-<2-(1-benzyloxycarbonylamino-2-methylpropyl)>-5-methyl-trans-oxazoline carboxylic acid (220717-55-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 94 percent / aq. NaOH / methanol / 1 h / 0 °C

With sodium hydroxide; In methanol;

DOI:10.1021/jo981664i

upstream raw materials:

(4S,5R)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

(4R,5R)-2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

(4S,5S)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Downstream raw materials:

2-((S)-1-{[2-((S)-1-{[(4S,5R)-2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester

2-((R)-1-{[(4S,5R)-2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid benzyl ester