methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

Base Information

Chemical Name:methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate
CAS No.:1365802-95-4
Molecular Formula:C₂₄H₁₅F₆N₃O₂
Molecular Weight:491.392
Hs Code.:

Synonyms:methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

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Chemical Property of methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

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Technology Process of methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

There total 3 articles about methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1365802-96-5
N-[3,5-bis(trifluoromethyl)phenyl]-4-chlorophthalazin-1-amine

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1365802-95-4
methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 110 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1365802-95-4
methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

With potassium phosphate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; mineral oil;

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 1365802-95-4
methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

With potassium phosphate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; mineral oil;