dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate

Base Information

• Chemical Name: dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate
• CAS No.: 1315510-22-5
• Molecular Formula: C₂₂H₁₆N₂O₄S₂
• Molecular Weight: 436.512
• Mol file: 1315510-22-5.mol

Synonyms:dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate

Chemical Property of dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate

There total 17 articles about dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester (7113-02-2) → dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate (1315510-22-5)

Guidance literature:

With silver(I) acetate; palladium diacetate; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 115 ℃; for 12h;

DOI:10.1016/j.tet.2011.05.123

Reference yield: 86.0%

triphenylphosphine (603-35-0) + 2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester (7113-02-2) → dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate (1315510-22-5) + methyl 2,5-diphenylthiazole-4-carboxylate (133415-16-4)

Guidance literature:

With silver(I) acetate; palladium diacetate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2013.02.001

Reference yield: 84.0%

tri(m-tolyl)phosphine (6224-63-1) + 2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester (7113-02-2) → dimethyl 2,2'-diphenyl-bis-5,5'-thiazole-4,4'-dicarboxylate (1315510-22-5) + methyl 2-phenyl-5-(3-methylphenyl)thiazole-4-carboxylate (1370731-60-4)

Guidance literature:

With silver(I) acetate; palladium diacetate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 48h; Concentration; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2013.02.001

upstream raw materials:

2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester

tert-Butyl methacrylate

acrylic acid n-butyl ester

para-xylene