diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate
CAS No.:149765-35-5
Molecular Formula:C₃₃H₄₆N₆O₆
Molecular Weight:622.765
Hs Code.:

Synonyms:diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Chemical Property of diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Technology Process of diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

There total 10 articles about diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 149765-34-4
diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

: 149765-35-5
diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; for 18h; under 2585.7 Torr;
DOI:10.3987/COM-92-S(T)65

Reference yield:

: 116387-21-4
4-iodobenzoyl-L-glutamic acid diethyl ester

: 149765-35-5
diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / copper(I) iodide, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triethylamine / dimethylformamide / 1.5 h / Ambient temperature

2: 76 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 18 h / 2585.7 Torr

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-92-S(T)65

Reference yield:

: 3282-30-2
pivaloyl chloride

: 149765-35-5
diethyl N-<2-pivaloylamino-4-diethylamino<(pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / pyridine / 0.5 h / Ambient temperature

2: 83 percent / N-iodosuccinimide / tetrahydrofuran / 1 h / Ambient temperature

3: 54 percent / copper(I) iodide, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triethylamine / dimethylformamide / 18 h / Ambient temperature

4: 80 percent / 2-methoxy-ethanol / 1 h / 100 °C

5: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

6: 45 percent / copper(I) iodide, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triethylamine / dimethylformamide / 1.5 h / Ambient temperature

7: 76 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 18 h / 2585.7 Torr

With pyridine; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-92-S(T)65