[2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester
• CAS No.: 1027222-64-5
• Molecular Formula: C₂₂H₂₆BrNO₄Si
• Molecular Weight: 476.442

Synonyms:[2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester

Chemical Property of [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester

There total 2 articles about [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl-(3-oxo-2,3-dihydro-1-benzofuran-6-yl)carbamate (857062-59-0) → [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester (1027222-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Br₂ / diethyl ether; dioxane

2: Et₃N / toluene

With bromine; triethylamine; In 1,4-dioxane; diethyl ether; toluene;

DOI:10.1002/ejoc.200400891

Reference yield:

(2-bromo-3-oxo-2,3-dihydro-benzofuran-6-yl)-carbamic acid benzyl ester (857062-46-5) + t-butyldimethylsiyl triflate (69739-34-0) → [2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester (1027222-64-5)

Guidance literature:

With triethylamine; In toluene;

DOI:10.1002/ejoc.200400891

Reference yield:

[2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester (1027222-64-5) + 4-Chlorophenylboronic acid (1679-18-1) → [3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester (857062-31-8)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 95 ℃;

DOI:10.1002/ejoc.200400891

upstream raw materials:

(2-bromo-3-oxo-2,3-dihydro-benzofuran-6-yl)-carbamic acid benzyl ester

t-butyldimethylsiyl triflate

benzyl-(3-oxo-2,3-dihydro-1-benzofuran-6-yl)carbamate

Downstream raw materials:

[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

[2-(4-chloro-phenyl)-3-oxo-2,3-dihydro-benzofuran-6-yl]-carbamic acid benzyl ester

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