2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

Base Information

Chemical Name:2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid
CAS No.:1389326-76-4
Molecular Formula:C₂₂H₂₄ClN₃O₄
Molecular Weight:429.903
Hs Code.:

Synonyms:2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

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Chemical Property of 2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

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Technology Process of 2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

There total 6 articles about 2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389327-11-0
methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

: 1389326-76-4
2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

Guidance literature:: methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate; With water; lithium hydroxide; In 1,4-dioxane; at 70 ℃; for 5h;

With hydrogenchloride; In water;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-76-4
2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 70 °C

With methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; water; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; lithium hydroxide; 10% Pt/activated carbon; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1389326-76-4
2-(4-((tert-butoxycarbonyl)amino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 70 °C

With methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; water; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; lithium hydroxide; 10% Pt/activated carbon; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;