(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

Base Information

Chemical Name:(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane
CAS No.:281190-99-6
Molecular Formula:C₂₉H₄₄O₂Si
Molecular Weight:452.753
Hs Code.:

Synonyms:(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

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Chemical Property of (1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

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Technology Process of (1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

There total 6 articles about (1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 281190-98-5
(3S,4R,5E)-1-(benzyloxy)-4-methyl-6-phenylhex-5-en-3-ol

: 281190-99-6
(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/ejoc.200300814

Reference yield:

: 2243-53-0,59744-46-6,1914-58-5
trans-styrylacetic acid

: 281190-99-6
(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMAP / CH₂Cl₂ / 1 h / 20 °C

1.2: 98 percent / EDCI / CH₂Cl₂ / 6 h / 20 °C

2.1: TiCl₄; iPrNEt / CH₂Cl₂ / 1 h / 20 °C

2.2: 98 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -78 °C

3.1: 92 percent / LAH / tetrahydrofuran / 1 h / 0 °C

4.1: phenyllithium; TsCl / tetrahydrofuran; cyclohexane; diethyl ether / 0.5 h / -78 - -20 °C

4.2: 96 percent / LAH / tetrahydrofuran; diethyl ether; cyclohexane / 0.33 h / -20 °C

5.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 20 h / 20 °C

With 2,6-dimethylpyridine; dmap; lithium aluminium tetrahydride; titanium tetrachloride; N-isopropylethylamine; phenyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1002/ejoc.200300814

Reference yield:

: 281190-97-4
(2R,3E,1'S,1''R,2''S)-1''-[(p-tolylsulfonyl)amino]indan-2''-yl 2-[3'-(benzyloxy)-1'-hydroxypropyl]-4-phenylbut-3-enoate

: 281190-99-6
(1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / LAH / tetrahydrofuran / 1 h / 0 °C

2.1: phenyllithium; TsCl / tetrahydrofuran; cyclohexane; diethyl ether / 0.5 h / -78 - -20 °C

2.2: 96 percent / LAH / tetrahydrofuran; diethyl ether; cyclohexane / 0.33 h / -20 °C

3.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 20 h / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; phenyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1002/ejoc.200300814