Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate

Base Information

• Chemical Name: Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate
• CAS No.: 91843-55-9
• Molecular Formula: C₁₂H₁₃BrO₂
• Molecular Weight: 269.138
• Mol file: 91843-55-9.mol

Synonyms:Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate

Chemical Property of Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate

There total 21 articles about Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diazoacetic acid ethyl ester (623-73-4) + 1-bromo-4-ethenyl-benzene (2039-82-9) → Ethyl trans-2-(4-bromophenyl)cyclopropanecarboxylate (91843-55-9)

Guidance literature:

rhodium⁽¹⁺⁾; at 100 ℃; for 4h;

DOI:10.1016/S0040-4039(97)10154-X

Reference yield: 72.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + diazoacetic acid ethyl ester (623-73-4) + 4-bromo-benzaldehyde (1122-91-4) → ethyl trans-2-(p-bromophenyl)-1-cyclopropanecarboxylate (53582-00-6,70461-61-9,91843-55-9)

Guidance literature:

diazoacetic acid ethyl ester; 4-bromo-benzaldehyde; With copper(l) iodide; triphenylphosphine; In dichloromethane; at 40 ℃; Inert atmosphere;

diazomethane; With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In dichloromethane; at -78 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1039/b810708d

Reference yield: 70.0%

diazoacetic acid ethyl ester (623-73-4) + 1-bromo-4-ethenyl-benzene (2039-82-9) → ethyl trans-2-(p-bromophenyl)-1-cyclopropanecarboxylate (53582-00-6,70461-61-9,91843-55-9) + cis-(1R,2S)/(1S,2R)-ethyl 2-(4-bromophenyl)cyclopropanecarboxylate (53582-00-6,70461-61-9,91843-55-9)

Guidance literature:

1-bromo-4-ethenyl-benzene; With tetrakis(acetonitrile)copper(I) tetrafluoroborate; In dichloromethane; at 20 ℃; Inert atmosphere;

diazoacetic acid ethyl ester; In dichloromethane; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1007/s00706-017-2026-5

upstream raw materials:

diazoacetic acid ethyl ester

1-bromo-4-ethenyl-benzene

α,α-diiodoethylacetate

4-Chlor-4-(4-brom-phenyl)-buttersaeureethylester

Downstream raw materials:

ethyl trans-2-(p-cyanophenyl)-1-cyclopropanecarboxylate

(±)-trans-O-tert-butyl-N-(2-(4-bromophenyl)cyclopropyl)carbamate

C₁₁H₉NO₂

(1S,2R)-(+)-2-(4-bromophenyl)cyclopropyl-1-amine