2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

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Chemical Name:2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one
CAS No.:1351218-01-3
Molecular Formula:C₂₂H₂₀BrCl₂N₅O
Molecular Weight:521.244
Hs Code.:

Synonyms:2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

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Chemical Property of 2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

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Technology Process of 2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

There total 4 articles about 2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1072138-63-6
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxaldehyde

: 926192-69-0
2-amino-5-chloro-N-cyclohexylbenzamide

: 1351218-01-3
2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 1h; Reflux;
DOI:10.1016/j.bmc.2013.06.060

Reference yield:

: 1351218-42-2
(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)methanol

: 1351218-01-3
2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 10 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 1 h / Reflux

With toluene-4-sulfonic acid; pyridinium chlorochromate; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.06.060

Reference yield:

: 500011-92-7
5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester

: 1351218-01-3
2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-3-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: pyridinium chlorochromate / dichloromethane / 10 h / 20 °C

3: toluene-4-sulfonic acid / toluene / 1 h / Reflux

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.06.060