ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Base Information

Chemical Name:ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate
CAS No.:1346223-05-9
Molecular Formula:C₂₃H₂₃NO₅S₂
Molecular Weight:457.571
Hs Code.:

Synonyms:ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

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Chemical Property of ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

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Technology Process of ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

There total 4 articles about ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1-[(4-methylthio)phenyl]-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

: 4755-77-5
Ethyl oxalyl chloride

: 1346223-05-9
ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃;

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 1346223-05-9
ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium peroxomonosulfate / methanol; water / 20 °C

2: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

3: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With potassium peroxomonosulfate; titanium tetrachloride; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm200715n

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1346223-05-9
ethyl 2-[1-(4-methylthiophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 0.25 h / 70 °C / 8791.75 Torr / Microwave irradiation

2: potassium peroxomonosulfate / methanol; water / 20 °C

3: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

4: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With potassium peroxomonosulfate; titanium tetrachloride; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; triethylamine; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm200715n