3,5-bis(trifluoromethyl)phenylzinc iodide

Base Information

• Chemical Name: 3,5-bis(trifluoromethyl)phenylzinc iodide
• CAS No.: 1357013-34-3
• Molecular Formula: C₈H₃F₆IZn
• Molecular Weight: 405.397
• Mol file: 1357013-34-3.mol

Synonyms:3,5-bis(trifluoromethyl)phenylzinc iodide

Chemical Property of 3,5-bis(trifluoromethyl)phenylzinc iodide

Chemical Property:

Purity/Quality:

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Technology Process of 3,5-bis(trifluoromethyl)phenylzinc iodide

There total 1 articles about 3,5-bis(trifluoromethyl)phenylzinc iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-bis(trifluoromethyl)iodobenzene (328-73-4) + zinc (7440-66-6) → 3,5-bis(trifluoromethyl)phenylzinc iodide (1357013-34-3)

Guidance literature:

zinc; With lithium chloride; at 150 - 170 ℃; for 2h; Inert atmosphere; Schlenk technique;

With chloro-trimethyl-silane; ethylene dibromide; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Glovebox;

3,5-bis(trifluoromethyl)iodobenzene; In tetrahydrofuran; for 24h; Inert atmosphere; Glovebox; Reflux;

DOI:10.1021/jacs.8b03163

Reference yield: 71.0%

3-(2-iodoethoxy)prop-1-ene (65805-36-9) + 3,5-bis(trifluoromethyl)phenylzinc iodide (1357013-34-3) → 3-(3,5-bis(trifluoromethyl)benzyl)tetrahydrofuran

Guidance literature:

With 2,2':6,2''-terpyridine; nickel dibromide; In tetrahydrofuran; at 50 ℃; for 6h; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.8b00184

Reference yield:

3,5-bis(trifluoromethyl)phenylzinc iodide (1357013-34-3) + 7-((4-methoxybenzyl)oxy)-1-(trimethylsilyl)hept-1-yn-3-yl (2,4,6-trimethoxyphenyl)carbonate (1357013-07-0) → (S)-(3-(3,5-bis(trifluoromethyl)phenyl)-7-((4-methoxybenzyl)oxy)hept-1-yn-1-yl)trimethylsilane (1375083-22-9) + (R)-(3-(3,5-bis(trifluoromethyl)phenyl)-7-((4-methoxybenzyl)oxy)hept-1-yn-1-yl)trimethylsilane (1357013-22-9)

Guidance literature:

With bis(tricyclohexylphosphine)nickel(II) dichloride; [3aS-[2(3'aRS,8'aSR),3aα,8aα]]-2,2'-(2,6-pyridinediyl)bis-[3a,8a-dihydro-8H-indeno[1,2-d]oxazole]; In tetrahydrofuran; 1,2-dimethoxyethane; at 10 ℃; for 20h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja300031w

upstream raw materials:

3,5-bis(trifluoromethyl)iodobenzene

zinc

Downstream raw materials:

(S)-(3-(3,5-bis(trifluoromethyl)phenyl)-7-((4-methoxybenzyl)oxy)hept-1-yn-1-yl)trimethylsilane

(R)-(3-(3,5-bis(trifluoromethyl)phenyl)-7-((4-methoxybenzyl)oxy)hept-1-yn-1-yl)trimethylsilane