N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

Base Information

Chemical Name:N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine
CAS No.:1381767-09-4
Molecular Formula:C₂₀H₂₂N₂O₂S
Molecular Weight:354.473
Hs Code.:

Synonyms:N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

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Chemical Property of N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

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Technology Process of N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

There total 6 articles about N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 881673-31-0
1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

: 557-66-4
ethanamine hydrochloride

: 1381767-09-4
N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 881673-29-6
ethyl 1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate

: 1381767-09-4
N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

3: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With tetrapropylammonium perruthennate; diisobutylaluminium hydride; sodium cyanoborohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1381767-09-4
N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)ethanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 0.75 h / 40 °C

1.2: 18.5 h / 20 °C

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 1 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

7.1: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014