N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide
CAS No.:1095002-36-0
Molecular Formula:C₂₃H₂₄N₄O₃
Molecular Weight:404.469
Hs Code.:

Synonyms:N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

There total 4 articles about N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6850-57-3
2-methoxybenzylamine

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 765-30-0
Cyclopropylamine

: 1095002-36-0
N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: 2-methoxybenzylamine; methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Cyclopropylamine; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

With palladium on activated charcoal; ammonium formate; In tetrahydrofuran; diethyl ether; ethanol; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095002-36-0
N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-benzene / 4 h / 100 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

2.2: 0.5 h / 20 °C

2.3: 1 h / 100 °C / Microwave irradiation

With triethylamine; In tetrahydrofuran; 1,2-dichloro-benzene;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1095002-36-0
N-cyclopropyl-3-[3-{[(2-methoxyphenyl)methyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 48 h / Reflux

2.1: 1,2-dichloro-benzene / 4 h / 100 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

3.2: 0.5 h / 20 °C

3.3: 1 h / 100 °C / Microwave irradiation

With triethylamine; In tetrahydrofuran; 1,2-dichloro-benzene;
DOI:10.1016/j.bmcl.2020.127412