methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Base Information

• Chemical Name: methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate
• CAS No.: 166666-78-0
• Molecular Formula: C₁₉H₁₉NO₅S
• Molecular Weight: 373.43
• Mol file: 166666-78-0.mol

Synonyms:methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Chemical Property of methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate

There total 4 articles about methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Benzenesulfonyl-bicyclo[1.1.0]butane-1-carboxylic acid methyl ester (117487-81-7) → methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate (166666-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetramethylguanidinium azide / CHCl₃; various solvent(s) / 20 h / 85 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature

3: pyridine / CH₂Cl₂

With pyridine; hydrogen; tetramethylguanidinum azide; palladium on activated charcoal; In dichloromethane; chloroform; ethyl acetate;

Reference yield:

1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylic acid → methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate (166666-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: H₂ / 10percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature

3: pyridine / CH₂Cl₂

With pyridine; hydrogen; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;

Reference yield:

methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117487-92-0) → methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate (166666-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature

2: pyridine / CH₂Cl₂

With pyridine; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

upstream raw materials:

benzoyl chloride

3-Benzenesulfonyl-bicyclo[1.1.0]butane-1-carboxylic acid methyl ester

methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate