methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Base Information

• Chemical Name: methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate
• CAS No.: 117487-92-0
• Molecular Formula: C₁₂H₁₃N₃O₄S
• Molecular Weight: 295.319
• Mol file: 117487-92-0.mol

Synonyms:methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Chemical Property of methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate

There total 3 articles about methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Benzenesulfonyl-bicyclo[1.1.0]butane-1-carboxylic acid methyl ester (117487-81-7) → methyl cis-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117488-00-3) + methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117487-92-0)

Guidance literature:

With tetramethylguanidinum azide; In chloroform; at 85 ℃; for 20h;

Reference yield:

3-Benzenesulfonyl-bicyclo[1.1.0]butane-1-carboxylic acid methyl ester (117487-81-7) → 1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylic acid + methyl cis-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117488-00-3) + methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117487-92-0)

Guidance literature:

With N,N,N',N'-tetramethylguanidinium azide; In chloroform; at 80 - 90 ℃; for 20h; Product distribution; further solvent and reagent;

DOI:10.1016/S0040-4039(00)80361-5

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylic acid → methyl cis-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117488-00-3) + methyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-carboxylate (117487-92-0)

Guidance literature:

In diethyl ether;

upstream raw materials:

3-Benzenesulfonyl-bicyclo[1.1.0]butane-1-carboxylic acid methyl ester

diazomethane

Downstream raw materials:

methyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-carboxylate