3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

Base Information

Chemical Name:3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine
CAS No.:131516-26-2
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:

Synonyms:3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

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Chemical Property of 3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

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Technology Process of 3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

There total 12 articles about 3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131516-17-1
3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

: 131516-26-2
3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 1h; Yield given;
DOI:10.1021/jo00002a077

Reference yield:

: 118922-26-2
3-(α-hydroxyimino-benzyl)-coumarin

: 131516-26-2
3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / triethylamine / CCl₄ / 1) 2 deg C, 15 min, 2) 25 deg C, 1 h

2: benzene / 2 h / 25 °C

3: potassium tert-butoxide / tetrahydrofuran / 1 h / -30 °C

4: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 1 h / 25 °C

5: 95 percent / 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

6: 95 percent / DMF, NaH / 1) 0 deg C to 25 deg C, 10 min, 2) 45 min

7: 76 percent / LiOH / dimethylsulfoxide; H₂O / 20 h / Heating

8: diphenyl phosphorazidate, triethylamine / benzene / 1) 25 deg C, 15 min, 2) reflux, 7 h

9: 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

With lithium hydroxide; diphenyl phosphoryl azide; potassium tert-butylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00002a077

Reference yield:

: 1846-74-8
3-benzoyl-chromen-2-one

: 131516-26-2
3-amino-6-methoxy-4-<2-<(methoxymethyl)oxy>phenyl>-5-methyl-2-phenylpyridine

Guidance literature:: Multi-step reaction with 10 steps

1: HONH₂*HCl, pyridine / ethanol

2: 75 percent / triethylamine / CCl₄ / 1) 2 deg C, 15 min, 2) 25 deg C, 1 h

3: benzene / 2 h / 25 °C

4: potassium tert-butoxide / tetrahydrofuran / 1 h / -30 °C

5: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 1 h / 25 °C

6: 95 percent / 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

7: 95 percent / DMF, NaH / 1) 0 deg C to 25 deg C, 10 min, 2) 45 min

8: 76 percent / LiOH / dimethylsulfoxide; H₂O / 20 h / Heating

9: diphenyl phosphorazidate, triethylamine / benzene / 1) 25 deg C, 15 min, 2) reflux, 7 h

10: 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

With pyridine; lithium hydroxide; diphenyl phosphoryl azide; hydroxylamine hydrochloride; potassium tert-butylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00002a077