3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

Base Information

Chemical Name:3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine
CAS No.:131516-17-1
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

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Chemical Property of 3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

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Technology Process of 3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

There total 12 articles about 3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1846-74-8
3-benzoyl-chromen-2-one

: 131516-17-1
3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

Guidance literature:: Multi-step reaction with 9 steps

1: HONH₂*HCl, pyridine / ethanol

2: 75 percent / triethylamine / CCl₄ / 1) 2 deg C, 15 min, 2) 25 deg C, 1 h

3: benzene / 2 h / 25 °C

4: potassium tert-butoxide / tetrahydrofuran / 1 h / -30 °C

5: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 1 h / 25 °C

6: 95 percent / 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

7: 95 percent / DMF, NaH / 1) 0 deg C to 25 deg C, 10 min, 2) 45 min

8: 76 percent / LiOH / dimethylsulfoxide; H₂O / 20 h / Heating

9: diphenyl phosphorazidate, triethylamine / benzene / 1) 25 deg C, 15 min, 2) reflux, 7 h

With pyridine; lithium hydroxide; diphenyl phosphoryl azide; hydroxylamine hydrochloride; potassium tert-butylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00002a077

Reference yield:

: 118922-26-2
3-(α-hydroxyimino-benzyl)-coumarin

: 131516-17-1
3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / triethylamine / CCl₄ / 1) 2 deg C, 15 min, 2) 25 deg C, 1 h

2: benzene / 2 h / 25 °C

3: potassium tert-butoxide / tetrahydrofuran / 1 h / -30 °C

4: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 1 h / 25 °C

5: 95 percent / 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

6: 95 percent / DMF, NaH / 1) 0 deg C to 25 deg C, 10 min, 2) 45 min

7: 76 percent / LiOH / dimethylsulfoxide; H₂O / 20 h / Heating

8: diphenyl phosphorazidate, triethylamine / benzene / 1) 25 deg C, 15 min, 2) reflux, 7 h

With lithium hydroxide; diphenyl phosphoryl azide; potassium tert-butylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00002a077

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 131516-17-1
3-Isocyanato-6-methoxy-4-(2-methoxymethoxy-phenyl)-5-methyl-2-phenyl-pyridine

Guidance literature:: Multi-step reaction with 10 steps

1: 80 percent / AcOH, piperidine / benzene / 3 h / 80 °C

2: HONH₂*HCl, pyridine / ethanol

3: 75 percent / triethylamine / CCl₄ / 1) 2 deg C, 15 min, 2) 25 deg C, 1 h

4: benzene / 2 h / 25 °C

5: potassium tert-butoxide / tetrahydrofuran / 1 h / -30 °C

6: 91 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 1 h / 25 °C

7: 95 percent / 4 N aq. LiOH / tetrahydrofuran / 1 h / 25 °C

8: 95 percent / DMF, NaH / 1) 0 deg C to 25 deg C, 10 min, 2) 45 min

9: 76 percent / LiOH / dimethylsulfoxide; H₂O / 20 h / Heating

10: diphenyl phosphorazidate, triethylamine / benzene / 1) 25 deg C, 15 min, 2) reflux, 7 h

With piperidine; pyridine; lithium hydroxide; diphenyl phosphoryl azide; hydroxylamine hydrochloride; potassium tert-butylate; sodium hydride; acetic acid; triethylamine; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00002a077