1846-74-8

Basic information

• Product Name: 3-Benzoylcoumarin
• Synonyms: 3-Benzoylcoumarin;3-benzoyl-2H-chroMen-2-one
• CAS NO: 1846-74-8
• Molecular Formula: C₁₆H₁₀O₃
• Molecular Weight: 250.25
• Mol File: 1846-74-8.mol
• Article Data: 42

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 447.7°C at 760 mmHg
• Flash Point: 202°C
• Appearance: /
• Density: 1.302g/cm³
• Vapor Pressure: 3.29E-08mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 3-Benzoylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzoylcoumarin(1846-74-8)
• EPA Substance Registry System: 3-Benzoylcoumarin(1846-74-8)

Safety Data

• Hazardous Substances Data: 1846-74-8(Hazardous Substances Data)

Usage

Uses

3-Benzoylcoumarin is a useful intermediate used in the synthesis of coumarin-chalcone derivatives with antibacterial properties for the treatment of tenacibaculosis.

InChI:InChI=1/C16H10O3/c17-15(11-6-2-1-3-7-11)13-10-12-8-4-5-9-14(12)19-16(13)18/h1-10H

Upstream product

• 20939-20-2 2-hydroxyphenyl-bis-1,1-piperidinomethane 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 614-16-4 Benzoylacetonitrile 
• 90-02-8 salicylaldehyde 
• 779-84-0 N-phenylsalicylaldimine 
• 55991-67-8 5-phenylfuran-2,3-dione 
• 89-95-2 2-methyl-benzyl alcohol 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 91-64-5 coumarin 
• 100-52-7 benzaldehyde 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 108-86-1 bromobenzene 

Downstream Products

• 59803-33-7 3-benzoyl-6-nitro-2H-chromen-2-one 
• 6272-41-9 2-phenylchromenylium perchlorate 
• 90-02-8 salicylaldehyde 
• 1194476-92-0 (3R,4S)-3-benzoyl-4-methylchroman-2-one 
• 1194476-52-2 (-)-(3R,4S)-3-benzoyl-4-methylchroman-2-one 
• 1194476-54-4 (3R,4S)-3-benzoyl-4-ethylchroman-2-one 
• 1354375-35-1 1,3-diphenyl-4H-furo[3,4-c]chromen-4-one 
• 1388215-77-7 3-benzoyl-1-hydroxy-4-(2-hydroxyphenyl)pyrrolidine-2,5-dione 
• 1416572-82-1 (1S,10bS)-1-ethyl-1,4-diphenyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1416573-02-8 (1R,10bR)-1-methyl-1,4-diphenyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1416572-83-2 (1S,10bS)-1-methyl-1,4-diphenyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1416572-84-3 (1S,10bS)-1,4-diphenyl-1-propyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 

Relevant articles and documents

Condensation of α-aroylketene dithioacetals and 2- hydroxyarylaldehydes results in facile synthesis of a combinatorial library of 3-aroylcoumarins

A facile, convenient, efficient, and high yielding synthesis of a combinatorial library of 3-aroylcoumarins has been developed by the condensation of easily available α-aroylketene dithioacetals (AKDTAs) and 2-hydroxybenzaldehydes (salicylaldehydes)/2-hydroxy-1-naphthaldehyde in the presence of catalytic amount of piperidine in THF reflux. The condensation of ferrocene derived α-aroylketene dithioacetal and 2-hydroxybenzaldehyde furnished coumarin installed on a ferrocene platform.

Analytical studies on isoxazoles. II. A new fluorimetric determination of 5-phenyl-3-isoxazolecarboxylic acid and its application to the determination of perisoxal in plasma

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The indium(iii) chloride catalyzed synthesis of sulfur incorporated 3-acylcoumarins; Their photochromic and acetate sensing properties

The synthesis and evaluation of the photochromic properties of 3-acylcoumarins are very important as they exhibit selective sensing properties. We found that InCl3 efficiently catalyzes the condensation of 2-hydroxybenzaldehydes and β-keto este

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Dual Role of Oxoaldehydes: Divergent Synthesis of 3-Aryl- and 3-Aroylcoumarins

A facile and efficient synthetic approach to various valuable 3-aryl- and 3-aroylcoumarins by the direct arylation and aroylation of coumarins with glyoxals in a metal-free manner is presented. The aryl glyoxal is for the first time recognized to serve as an aryl surrogate in addition to its role as an aroyl transfer reagent via a simple switch in reaction conditions. The approach accommodates a broad substrate scope and high yields of the two types of cross-coupling reactions starting from identical starting materials.

Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts

A series of novel 3-benzylcoumarin-imidazolium salts were prepared and evaluated in vitro against a panel of human tumor cell lines. The results showed that the existence of 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position wit