1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:247579-49-3
Molecular Formula:C₂₀H₂₄BrNO₄
Molecular Weight:422.319
Hs Code.:

Synonyms:1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 11 articles about 1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 121089-92-7
1-(2-bromo-4,5-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline

: 247579-49-3
1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.25h;
DOI:10.1021/jo982451w

Reference yield:

: 155826-73-6
N-[2-[1-(3,4-dimethoxyphenyl)]ethyl]-2-bromo-3,4-dimethoxyphenylacetamide

: 247579-49-3
1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / POCl₃ / toluene / 3 h / Heating

2: 100 percent / NaBH₄ / methanol / 0.25 h

With sodium tetrahydroborate; trichlorophosphate; In methanol; toluene; 1: Cyclization / 2: Reduction;
DOI:10.1021/jo982451w

Reference yield:

: 55171-60-3
2-bromo-3,4-dimethoxybenzylaldehyde

: 247579-49-3
1-(2'-bromo-3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h

2: SOCl₂ / benzene / 20 °C

3: dimethylsulfoxide; benzene / 2 h

4: 92 percent / 4N NaOH / ethanol / 20 h / Heating

5: SOCl₂ / benzene / 2 h / 50 - 60 °C

6: 91 percent / benzene; pyridine / 20 °C

7: 85 percent / POCl₃ / toluene / 3 h / Heating

8: 100 percent / NaBH₄ / methanol / 0.25 h

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; ethanol; dimethyl sulfoxide; toluene; benzene; 1: Reduction / 2: Substitution / 3: Substitution / 4: Hydrolysis / 5: Substitution / 6: Acylation / 7: Cyclization / 8: Reduction;
DOI:10.1021/jo982451w