4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide
CAS No.:1362818-56-1
Molecular Formula:C₂₅H₂₂F₃N₃O₄
Molecular Weight:485.463
Hs Code.:

Synonyms:4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

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Chemical Property of 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

There total 12 articles about 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: C₂₀H₁₈F₃NO₅

: 1362818-56-1
4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: pyridin-3-ylamine; C₂₀H₁₈F₃NO₅; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 81245-24-1
methyl 4-methyl-2-methoxybenzoate

: 1362818-56-1
4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 11 steps

1: bromine / chloroform / 1.08 h / 0 °C

2: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

3: boron tribromide / dichloromethane / 2 h / 0 °C

4: pyridine / 2 h

5: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

6: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

7: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C

8: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

9: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

10: water; lithium hydroxide / tetrahydrofuran / 1 h / 45 °C

11: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h

With pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; boron tribromide; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362818-56-1
4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 12 steps

1: potassium carbonate / acetone / 5 h / 50 °C

2: bromine / chloroform / 1.08 h / 0 °C

3: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

4: boron tribromide / dichloromethane / 2 h / 0 °C

5: pyridine / 2 h

6: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

7: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

8: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C

9: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

10: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

11: water; lithium hydroxide / tetrahydrofuran / 1 h / 45 °C

12: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h

With pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; boron tribromide; potassium carbonate; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;