3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Base Information

• Chemical Name: 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile
• CAS No.: 159685-77-5
• Molecular Formula: C₂₀H₁₃FN₂O
• Molecular Weight: 316.334
• Mol file: 159685-77-5.mol

Synonyms:3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Chemical Property of 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Chemical Property:

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3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile ^*data from reagent suppliers

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Technology Process of 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

There total 2 articles about 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluorobenzaldehyde (459-57-4) + β-naphthol (135-19-3) + malononitrile (109-77-3) → 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile (159685-77-5)

Guidance literature:

With N-allyl-N'-methylimidazolium iodide; In neat (no solvent); at 80 ℃; for 0.916667h; Green chemistry;

Reference yield:

4-fluorobenzaldehyde (459-57-4) + β-naphthol (135-19-3) + malononitrile (109-77-3) → 14-(4-fluorophenyl)-14H-dibenzo[a.j]xanthene (37096-99-4) + 3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile (159685-77-5)

Guidance literature:

With zirconia/phosphotungstic acid composite; In neat (no solvent); at 130 ℃; for 3h; Temperature; Catalytic behavior;

DOI:10.1080/00304948.2018.1549903

Reference yield: 91.0%

3-amino-1-(4-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile (159685-77-5) + acetic acid (64-19-7,77671-22-8) → 12-(4-fluorophenyl)-9-methyl-10,12-dihydro-11H-benzo[f]chromeno[2,3-d]pyrimidin-11-one

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1080/00304948.2019.1596472

upstream raw materials:

4-fluorobenzaldehyde

β-naphthol

malononitrile

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