(S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Base Information

• Chemical Name: (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester
• CAS No.: 476374-16-0
• Molecular Formula: C₂₆H₂₈N₄O₇
• Molecular Weight: 508.531

Synonyms:(S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Chemical Property of (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

There total 4 articles about (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

diethyl-L-glutamate hydrochloride (1118-89-4) + 3-(4-carboxymethyl-phenylamino)-quinoxaline-2-carboxylic acid (476374-10-4) → (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-16-0) + (S)-2-[(3-{4-[((S)-1,3-Bis-ethoxycarbonyl-propylcarbamoyl)-methyl]-phenylamino}-quinoxaline-2-carbonyl)-amino]-pentanedioic acid diethyl ester

Guidance literature:

With diethyl cyanophosphonate; triethylamine; at 20 ℃; for 2h;

DOI:10.1016/S0014-827X(01)01159-4

Reference yield:

ethyl 3-chloroquinoxaline-2-carboxylate (49679-45-0) → (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / ethanol / 13 h / Heating

2: 95 percent / aq. NaOH / ethanol / 4 h / Heating

3: 38 percent / (EtO)2POCN; Et₃N / 2 h / 20 °C

With sodium hydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;

DOI:10.1016/S0014-827X(01)01159-4

Reference yield:

ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0) → (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / ethanol / 13 h / Heating

2: 95 percent / aq. NaOH / ethanol / 4 h / Heating

3: 38 percent / (EtO)2POCN; Et₃N / 2 h / 20 °C

With sodium hydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;

DOI:10.1016/S0014-827X(01)01159-4

upstream raw materials:

diethyl-L-glutamate hydrochloride

3-(4-carboxymethyl-phenylamino)-quinoxaline-2-carboxylic acid

ethyl 3-chloroquinoxaline-2-carboxylate

ethyl (4-amino-3,5-dibromophenyl)acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 476374-16-0 (S)-2-{2-[4-(3-Carboxy-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send