Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester
CAS No.:190968-29-7
Molecular Formula:C₅₀H₆₂N₅O₁₀PSi
Molecular Weight:952.129
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

Synonyms:Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

There total 4 articles about Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 107-66-4
dibutyl phosphate

: 190968-28-6
N-{9-[(2R,3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 190968-29-7
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

Guidance literature:: With N-iodo-succinimide; In tetrahydrofuran; 1,2-dichloro-ethane; for 5h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00308-6

Reference yield:

: 80015-58-3
N⁶-benzoyl-2'-O-(p-methoxybenzyl)adenosine

: 190968-29-7
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / DMAP / pyridine / 2 h / Ambient temperature

2: 60 percent / 2,6-lutidine, benzoyl peroxide / acetonitrile / 0.5 h / Ambient temperature

3: 72 percent / NIS / 1,2-dichloro-ethane; tetrahydrofuran / 5 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; N-iodo-succinimide; Perbenzoic acid; In tetrahydrofuran; pyridine; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/S0040-4020(97)00308-6

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 190968-29-7
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yloxymethyl ester dibutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / DMAP / pyridine / 2 h / Ambient temperature

2: 60 percent / 2,6-lutidine, benzoyl peroxide / acetonitrile / 0.5 h / Ambient temperature

3: 72 percent / NIS / 1,2-dichloro-ethane; tetrahydrofuran / 5 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; N-iodo-succinimide; Perbenzoic acid; In tetrahydrofuran; pyridine; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/S0040-4020(97)00308-6