benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

Base Information

Chemical Name:benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate
CAS No.:1352836-16-8
Molecular Formula:C₂₅H₂₂BrN₃O₄
Molecular Weight:508.371
Hs Code.:

Synonyms:benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

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Chemical Property of benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

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Technology Process of benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

There total 5 articles about benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

: 52415-29-9
6-bromo-1H-indole

: 1352835-04-1
(E)-benzyl 2-methyl-3-(2-nitrovinyl)phenylcarbamate

: 1352836-16-8
benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

Guidance literature:: at 120 - 125 ℃; for 22h;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352836-16-8
benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

4.1: 22 h / 120 - 125 °C

With ammonium acetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352836-16-8
benzyl 3-(1-(6-bromo-1H-indol-3-yl)-2-nitroethyl)-2-methylphenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

4.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

5.1: 22 h / 120 - 125 °C

With ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;