Technology Process of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-bromo-9H-pyrido[3,4-b]indole-1-carboxylate
There total 7 articles about ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-bromo-9H-pyrido[3,4-b]indole-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
glyoxylic acid ethyl ester; benzyl 3-(2-amino-1-(6-bromo-1H-indol-3-yl)ethyl)-2-methylphenylcarbamate;
With
hydrogenchloride;
In
tetrahydrofuran; 1,4-dioxane; toluene;
at 20 ℃;
for 24h;
Molecular sieve;
With
sodium hydrogencarbonate;
In
water;
With
oxygen;
palladium 10% on activated carbon;
In
para-xylene;
at 1250 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C
2.2: 0.5 h / 20 °C / Cooling with ice
3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C
4.1: 22 h / 120 - 125 °C
5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 7 h / 0 - 20 °C
6.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 24 h / 20 °C / Molecular sieve
6.3: 16 h / 1250 °C
With
hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C
2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C
3.2: 0.5 h / 20 °C / Cooling with ice
4.1: ammonium acetate; acetic acid / 4.5 h / 90 °C
5.1: 22 h / 120 - 125 °C
6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 7 h / 0 - 20 °C
7.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 24 h / 20 °C / Molecular sieve
7.3: 16 h / 1250 °C
With
hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
