2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester
CAS No.:660395-92-6
Molecular Formula:C₅₈H₇₂N₄O₁₇
Molecular Weight:1097.23
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-methyl-butyric acid 10-(2-<i>tert</i>-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-<i>tert</i>-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6<i>H</i>-5-oxa-6b-aza-dibenzo[<i>a</i>,<i>i</i>]fluoren-3-yl ester

Synonyms:2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

There total 6 articles about 2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 660395-88-0
C₅₈H₇₄N₄O₁₇

: 660395-92-6
2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrachloromethane; for 5h; Heating;
DOI:10.1016/j.bmc.2004.01.020

Reference yield: 88.0%

: 660395-92-6
2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:

Reference yield:

: 6-isopropoxy-7-methoxy-3,4-dihydroisoquinoline

: 660395-92-6
2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,2-dichloro-ethane / 8 h / 23 °C

1.2: 47 percent / DIPEA / 1,2-dichloro-ethane / 32 h / 85 °C

2.1: 97 percent / AlCl₃ / CH₂Cl₂ / 2.5 h / 23 °C

3.1: 79 percent / EDC*HCl; DMAP / CH₂Cl₂ / 4 h / 23 °C

4.1: 88 percent / DDQ / CCl₄ / 5 h / Heating

With dmap; aluminium trichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.01.020