N-BENZYL-GUANIDINE

Base Information

• Chemical Name: N-BENZYL-GUANIDINE
• CAS No.: 117053-38-0
• Molecular Formula: C₂H₄O₂*C₈H₁₁N₃
• Molecular Weight: 209.248
• Hs Code.: 2925290090
• Mol file: 117053-38-0.mol

Synonyms:N-benzylquanidine acetate

Chemical Property of N-BENZYL-GUANIDINE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-Benzyl-guanidineAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Benzylguanidine is a useful building block and has been used in the synthesis of novel substituted 2-(2-aminopyrimidin-4-yl) pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases in human esophageal squamous cell carcinoma cells.

Technology Process of N-BENZYL-GUANIDINE

There total 1 articles about N-BENZYL-GUANIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-Dimethylpyrazole-1-carboxamidine (22906-75-8) + benzylamine (100-46-9) → N-benzylquanidine acetate (117053-38-0)

Guidance literature:

With acetic acid; In toluene; for 16h; Yield given; Heating;

DOI:10.1016/S0040-4020(01)85939-1

Reference yield: 53.0%

2,6-diethylphenylisocyanate (20458-99-5) + N-benzylquanidine acetate (117053-38-0) → N-(2,6-diethylphenyl)-N'-[imino(benzylamino)methyl]urea

Guidance literature:

With potassium hydroxide; In water; acetone; Reflux;

DOI:10.1021/acs.jmedchem.1c01565

Reference yield:

p-Nitrophenyl 3-bromo-2,2-diethoxy-propionate (87224-03-1) + N-benzylquanidine acetate (117053-38-0) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2-Benzylamino-5,5-diethoxy-5,6-dihydro-3H-pyrimidin-4-one (117053-44-8)

Guidance literature:

With sodium; Yield given. Multistep reaction; 1.) ethanol, room t., 1 h, 2.) ethanol, reflux, 16 h;

DOI:10.1016/S0040-4020(01)85939-1

upstream raw materials:

3,5-Dimethylpyrazole-1-carboxamidine

benzylamine

Downstream raw materials:

4-nitro-phenol

2-Benzylamino-5,5-diethoxy-5,6-dihydro-3H-pyrimidin-4-one

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