20458-99-5

Basic information

• Product Name: 2,6-DIETHYLPHENYL ISOCYANATE
• Synonyms: 2,6-DIETHYLPHENYL ISOCYANATE;2,6-DIETHYLPHENYL ISOCYANATE, 98+%;1,3-diethyl-2-isocyanatobenzene
• CAS NO: 20458-99-5
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Product Categories: Isocyanates;Nitrogen Compounds;Organic Building Blocks
• Mol File: 20458-99-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 115 °C1 mm Hg(lit.)
• Flash Point: 220 °F
• Appearance: /
• Density: 1.014 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0127mmHg at 25°C
• Refractive Index: n20/D 1.528(lit.)
• Sensitive: Moisture Sensitive
• BRN: 2641462
• CAS DataBase Reference: 2,6-DIETHYLPHENYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIETHYLPHENYL ISOCYANATE(20458-99-5)
• EPA Substance Registry System: 2,6-DIETHYLPHENYL ISOCYANATE(20458-99-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN 2206 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 20458-99-5(Hazardous Substances Data)

Usage

General Description

2,6-Diethylphenyl isocyanate is a chemical compound with the molecular formula C11H13NO. It is a colorless to pale yellow liquid that is primarily used in the production of polyurethane foams and coatings. It is classified as a hazardous substance and can cause irritation to the skin, eyes, and respiratory system upon prolonged exposure. It is also a potential carcinogen and mutagen. Due to its potential health risks, proper safety measures and handling procedures should be followed when working with 2,6-diethylphenyl isocyanate.

InChI:InChI=1/C11H13NO/c1-3-9-6-5-7-10(4-2)11(9)12-8-13/h5-7H,3-4H2,1-2H3

Upstream product

• 579-66-8 2,6-diethylaniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 124-38-9 carbon dioxide 

Downstream Products

• 97627-22-0 N-(2,6-diethylphenyl)-N'-4-pyridinyl urea 
• 67165-57-5 1-[1-Amino-1-methylamino-meth-(Z)-ylidene]-3-(2,6-diethyl-phenyl)-urea 
• 38145-72-1 1-{[(E)-4-Chloro-2-methyl-phenylimino]-methyl}-3-(2,6-diethyl-phenyl)-1-methyl-urea 
• 65009-19-0 N-(2,6-diethylphenyl)-N'-[(ethylamino)iminomethyl]urea 
• 55832-01-4 1-(2',6'-diethylphenyl)-3-amidinourea 

Relevant articles and documents

With anti-tumor effect of a quinazoline-urea derivative and its application (by machine translation)

The present invention relates to a of the general formula (II) anti-tumor function of said quinazoline-urea derivative and its application. The definition of the substituent in the general formula (II) in the specification. This invention, in order to SUO draw non-Buddhist nun and Geftinat compounds as the precursor, retention of SUO draw non-Buddhist nun the pharmocology-carbamido; at the same time, such as in reserved [...] EGFR-TKIs Geftinat, synthesis, and obtain a series of quinazoline-urea derivatives, by the in vitro activity tests, some compounds exhibit excellent anti-tumor activity, such derivatives have high research and utility value. (II). (by machine translation)

Novel specific puromycin-sensitive aminopeptidase inhibitors: 3-(2,6-diethylphenyl)-2,4(1H, 3H)-quinazolinedione and N-(2,6-diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one

Novel specific PSA (puromycin-sensitive aminopeptidase) inhibitors, 3-(2,6-diethylphenyl)-2,4(1H, 3H)-quinazolinedione (3: PAQ-22) and N-(2,6-diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one (4: PAZOX-22), were designed and synthesized. These compounds are chemically much more stable than the known specific PSA inhibitor PIQ-22 (2), and the enzyme specificity and inhibitory activity to PSA are similar to those of 2. The inhibitory manner of these compounds was found to be a non-competitive mode by Lineweaver- Burk plot analysis.

A Mitsunobu-based procedure for the preparation of alkyl and hindered aryl isocyanates from primary amines and carbon dioxide under mild conditions

A Mitsunobu-based procedure for the preparation of alkyl and hindered aryl isocyanates in excellent yields from primary amines and carbon dioxide under very mild conditions is described.