5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Base Information

• Chemical Name: 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide
• CAS No.: 1290633-68-9
• Molecular Formula: C₁₉H₂₇N₅O₄
• Molecular Weight: 389.454
• Mol file: 1290633-68-9.mol

Synonyms:5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Chemical Property of 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

There total 3 articles about 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (909391-53-3) + 1,4-diazabicyclo[3.2.2]nonane dihydrochloride (150208-70-1) → 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (1290633-68-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 96 ℃;

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (1290633-68-9)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 2.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

3: potassium carbonate / acetonitrile / 96 °C

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

Reference yield:

5-fluoro-2-nitrobenzoyl chloride (394-02-5) → 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (1290633-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

2: potassium carbonate / acetonitrile / 96 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

upstream raw materials:

5-fluoro-2-nitrobenzoyl chloride

5-fluoro-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

1,4-diazabicyclo[3.2.2]nonane dihydrochloride

5-fluoro-2-nitrobenzoic acid

Downstream raw materials:

2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide

2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide