2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide

Base Information

• Chemical Name: 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide
• CAS No.: 1290634-61-5
• Molecular Formula: C₂₆H₂₉ClFN₅O₂
• Molecular Weight: 498
• Mol file: 1290634-61-5.mol

Synonyms:2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide

Chemical Property of 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide

There total 5 articles about 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide (1019971-36-8) + 3-chloro-5-fluoro-benzaldehyde (90390-49-1) → 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide (1290634-61-5)

Guidance literature:

2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide; 3-chloro-5-fluoro-benzaldehyde; acetic acid; In ethanol; at 95 ℃; for 24h; Sealed reactivial;

With manganese(IV) oxide; In dichloromethane;

Reference yield:

5-fluoro-2-nitrobenzoyl chloride (394-02-5) → 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide (1290634-61-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

2: potassium carbonate / acetonitrile / 96 °C

3: hydrogen / palladium on carbon / methanol / 20 °C / 3000.3 Torr

4: acetic acid / ethanol / 24 h / 95 °C / Sealed reactivial

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on carbon; acetic acid; In methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

5-fluoro-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (909391-53-3) → 2-(6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chloro-5-fluorophenyl)-4-oxoquinazolin-3(4H)-yl)-N-isopropylacetamide (1290634-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 96 °C

2: hydrogen / palladium on carbon / methanol / 20 °C / 3000.3 Torr

3: acetic acid / ethanol / 24 h / 95 °C / Sealed reactivial

With hydrogen; potassium carbonate; palladium on carbon; acetic acid; In methanol; ethanol; acetonitrile;

upstream raw materials:

5-fluoro-2-nitrobenzoyl chloride

5-fluoro-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide

2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide

3-chloro-5-fluoro-benzaldehyde