7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

Base Information

Chemical Name:7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III
CAS No.:110258-95-2
Molecular Formula:C₃₇H₄₀Cl₆O₁₅
Molecular Weight:937.434
Hs Code.:

Synonyms:7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

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Chemical Property of 7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

Chemical Property:

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Technology Process of 7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

There total 3 articles about 7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

: 1219592-94-5
(2R,3S)-N,N-di-Boc-2-acetyl-3-phenylisoserine

: 95603-44-4
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

: 1227402-71-2
7,10-di-troc-N'-Boc-2'-acetyldocetaxel

: 110258-95-2
7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 15 - 20 ℃; Temperature;
DOI:10.1002/cjoc.201201142

Reference yield:

: 95603-44-4
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

: 75-36-5
acetyl chloride

: 110258-95-2
7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

Guidance literature:: With silver cyanide; In toluene; at 80 ℃; for 3h;
DOI:10.1016/S0040-4020(01)87285-9

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 110258-95-2
7,10-di(2,2,2-tricholoroethyloxycarbonyl)-13-acetyl-10-deacetyl baccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 153 mg / pyridine / 0.08 h / 80 °C

2: 46 mg / silver cyanide / toluene / 3 h / 80 °C

With silver cyanide; In pyridine; toluene;
DOI:10.1016/S0040-4020(01)87285-9