1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol

Base Information

• Chemical Name: 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol
• CAS No.: 208102-90-3
• Molecular Formula: C₃₆H₄₄O₄
• Molecular Weight: 540.743
• Mol file: 208102-90-3.mol

Synonyms:1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol

Chemical Property of 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol

There total 7 articles about 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol (208102-90-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / MCPBA / CH₂Cl₂ / 12 h / Ambient temperature

2: 96 percent / NaOH / methanol / 0.08 h / Ambient temperature

3: 1.) NaH / 1.) THF, room temperature, 15 min, 2.) 80 deg C, 4 h.

4: 1.) n-BuLi, TMEDA / 1.) Et₂O, hexane, 0 deg C, 30 min, 2.) Et₂O, 0 deg C, 1 h.

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1016/S0040-4020(98)00235-X

Reference yield:

benzyl bromide (100-39-0) → 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol (208102-90-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / K₂CO₃ / acetone / 15 h / Heating

2: 96 percent / MCPBA / CH₂Cl₂ / 12 h / Ambient temperature

3: 96 percent / NaOH / methanol / 0.08 h / Ambient temperature

4: 1.) NaH / 1.) THF, room temperature, 15 min, 2.) 80 deg C, 4 h.

5: 1.) n-BuLi, TMEDA / 1.) Et₂O, hexane, 0 deg C, 30 min, 2.) Et₂O, 0 deg C, 1 h.

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4020(98)00235-X

Reference yield:

3,4-dihydroxybenzaldehyde (139-85-5) → 1,2-di-O-benzyl-3-(11'-hydroxy-8'-drimen-11'-yl)-4-O-methylbenzenetriol (208102-90-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / K₂CO₃ / acetone / 15 h / Heating

2: 96 percent / MCPBA / CH₂Cl₂ / 12 h / Ambient temperature

3: 96 percent / NaOH / methanol / 0.08 h / Ambient temperature

4: 1.) NaH / 1.) THF, room temperature, 15 min, 2.) 80 deg C, 4 h.

5: 1.) n-BuLi, TMEDA / 1.) Et₂O, hexane, 0 deg C, 30 min, 2.) Et₂O, 0 deg C, 1 h.

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4020(98)00235-X

upstream raw materials:

(4aS,8aS)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethylnaphthalene-1-carboxaldehyde

1,2-dibenzyloxy-4-methoxybenzene

3,4-dibenzyloxybenzaldehyde

3,4-dibenzyloxyphenol

Downstream raw materials:

1,2-di-O-benzyl-3-(8'-drimen-11'-yl)-4-O-methylbenzenetriol