2,4-Difluoro-6-nitrophenol

Base Information

• Chemical Name: 2,4-Difluoro-6-nitrophenol
• CAS No.: 364-31-8
• Molecular Formula: C6H3F2NO3
• Molecular Weight: 175.092
• Hs Code.: 2908999090
• NSC Number: 10261
• DSSTox Substance ID: DTXSID10278834
• Wikidata: Q72463553
• Mol file: 364-31-8.mol

Synonyms:2,4-Difluoro-6-nitrophenol;364-31-8;Phenol, 2,4-difluoro-6-nitro-;2,4-Difluoro-6-nitro-phenol;MFCD03094186;NSC10261;6-chloronicotinylchloride;SCHEMBL2078816;2,4-Difluoro-6-nitrophenol #;DTXSID10278834;NSC-10261;AKOS009159499;DS-5121;SY280376;A6299;CS-0134477;FT-0632044;EN300-199434

Chemical Property of 2,4-Difluoro-6-nitrophenol

Chemical Property:

• Vapor Pressure: 0.34mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 211.1°Cat760mmHg
• PKA: 5.32±0.38(Predicted)
• Flash Point: 81.4°C
• PSA: 66.05000
• Density: 1.619g/cm³
• LogP: 2.10180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 175.00809928
• Heavy Atom Count: 12
• Complexity: 184

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoro-6-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)F)F

Technology Process of 2,4-Difluoro-6-nitrophenol

There total 1 articles about 2,4-Difluoro-6-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,4-difluorophenol (367-27-1) → 2,4-difluoro-6-nitro-phenol (364-31-8)

Guidance literature:

With nitric acid; acetic acid; at 10 ℃; for 1.5h;

Reference yield: 73.0%

2,4-difluoro-6-nitro-phenol (364-31-8) + 2-bromoethanol (540-51-2) → C8H7F2NO4

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

Reference yield:

2,4-difluorophenol (367-27-1) + 2,4-difluoro-6-nitro-phenol (364-31-8) → 2,4-Difluoro-6-aminophenol Hydrochloride

Guidance literature:

With hydrogenchloride; H₂; nitrogen; palladium; In methanol;

upstream raw materials:

2,4-difluorophenol

Refernces

• 1、 -. "4,5,6,7-trisubstituted benzoxazolones". . . Retrieved 2008/06/13.