ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Base Information

Chemical Name:ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate
CAS No.:1366061-66-6
Molecular Formula:C₂₈H₂₆ClF₆N₅O₆
Molecular Weight:677.988
Hs Code.:

ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Synonyms:ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

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Chemical Property of ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

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Technology Process of ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

There total 11 articles about ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1366063-16-2
ethyl 1-({amino[3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate hydrochloride

: 1366061-66-6
ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1228650-21-2
ethyl N-({2-[(4-chlorophenyl)carbonyl]hydrazinyl}carbonyl)glycinate

: 1366061-66-6
ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; sodium hydroxide / Reflux

2.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

2.2: 70 °C

3.1: methanol; sodium tetrahydroborate / 1.5 h / Cooling with ice

4.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

5.1: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide, 430 mm×40 mm / 2-Methylpentane; ethyl acetate / Resolution of racemate

6.1: water; lithium hydroxide / methanol / 1 h / 20 °C

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; lithium hydroxide; In methanol; 2-Methylpentane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1366061-66-6
ethyl 1-({[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 2 h / 50 °C

2.1: water; sodium hydroxide / Reflux

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: methanol; sodium tetrahydroborate / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide, 430 mm×40 mm / 2-Methylpentane; ethyl acetate / Resolution of racemate

7.1: water; lithium hydroxide / methanol / 1 h / 20 °C

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; 2-Methylpentane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;