N-(tert-Butyl)-N-methylformamide

Base Information

• Chemical Name: N-(tert-Butyl)-N-methylformamide
• CAS No.: 63957-05-1
• Molecular Formula: C6H13 N O
• Molecular Weight: 115.175
• Hs Code.: 2924199090
• Mol file: 63957-05-1.mol

Synonyms:Formamide,N-tert-butyl-N-methyl- (7CI)

Chemical Property of N-(tert-Butyl)-N-methylformamide

Chemical Property:

• Vapor Pressure: 0.669mmHg at 25°C
• Boiling Point: 186.3°C at 760 mmHg
• PKA: -0.44±0.70(Predicted)
• Flash Point: 69.8°C
• PSA: 20.31000
• Density: 0.871g/cm³
• LogP: 1.50900

Purity/Quality:

N(TERTBUTYL)N-METHYLFORMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(tert-Butyl)-N-methylformamide

There total 1 articles about N-(tert-Butyl)-N-methylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine (85462-16-4) + pivalaldehyde (630-19-3) → N-methyl-pivalamide (6830-83-7) + N-methyl-N-tert-butylformamide (63957-05-1)

Guidance literature:

In chloroform-d1; for 6h; Ambient temperature;

DOI:10.1021/jo00042a032

Reference yield: 83.0%

N-methyl-N-tert-butylformamide (63957-05-1) + 2,3-diphenyl-2H-azirine (16483-98-0) → trans-N-(tert-butyl)-N-methyl-2,3-diphenylaziridine-2-carboxamide

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.5h; diastereoselective reaction;

DOI:10.1021/acs.orglett.1c01334

Reference yield: 81.0%

N-methyl-N-tert-butylformamide (63957-05-1) + C13H17N → N-(tert-butyl)-N-methyl-2-phenyl-1-azaspiro[2.5]octane-2-carboxamide

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.5h;

DOI:10.1021/acs.orglett.1c01334

upstream raw materials:

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine

pivalaldehyde

Downstream raw materials:

N-methyl-tert-butylamine

N-(tert-butyl)-2-(tert-butyl(hydroxy)amino)-2-(4-methoxyphenyl)-N-methylacetamide

(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromophenyl)-N-(tert-butyl)-N-methylacetamide

(R)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromophenyl)-N-(tert-butyl)-N-methylacetamide

Refernces