(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

Base Information

Chemical Name:(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine
CAS No.:153108-87-3
Molecular Formula:C₂₃H₃₄INO₂
Molecular Weight:483.433
Hs Code.:

Synonyms:(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

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Chemical Property of (2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

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Technology Process of (2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

There total 12 articles about (2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 153108-86-2
(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

: 153108-87-3
(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

Guidance literature:: With dimethylboron bromide; In dichloromethane; at -78 ℃; for 2h;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 153108-87-3
(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / Ph₃P / acetonitrile / 1 h / Heating

2: 85 percent / tetrahydrofuran / 0 °C

3: CH₂Cl₂ / Ambient temperature

4: 1.) BuLi / 1.) hexane, THF, -30 deg C to -20 deg C, 1.5 h, 2.) hexane, THF, -78 deg C, 30 min

5: 68 percent / Hg(ClO₄)2*3H₂O / CHCl₃ / 3 h / Ambient temperature

6: 89 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

7: 91 percent / KH / tetrahydrofuran / 2 h / Heating

8: 95 percent / AgNO₃ / ethanol / 1 h / Ambient temperature

9: 69 percent / i-Pr₂NEt / tetrahydrofuran / 48 h / Ambient temperature

10: 67 percent / Me₂BBr / CH₂Cl₂ / 2 h / -78 °C

With n-butyllithium; mercury(II) perchlorate; dimethylboron bromide; potassium hydride; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetonitrile;

Reference yield:

: 91550-08-2
(S)-2-acetylpyrrolidine-1-carboxylic acid tert-butyl ester

: 153108-87-3
(2S)-2-<(R)-1-(benzyloxy)-1-formylethyl>-N-<(E)-(R)-2-iodo-4-methyl-2-octenyl>pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: CH₂Cl₂ / Ambient temperature

2: 1.) BuLi / 1.) hexane, THF, -30 deg C to -20 deg C, 1.5 h, 2.) hexane, THF, -78 deg C, 30 min

3: 68 percent / Hg(ClO₄)2*3H₂O / CHCl₃ / 3 h / Ambient temperature

4: 89 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

5: 91 percent / KH / tetrahydrofuran / 2 h / Heating

6: 95 percent / AgNO₃ / ethanol / 1 h / Ambient temperature

7: 69 percent / i-Pr₂NEt / tetrahydrofuran / 48 h / Ambient temperature

8: 67 percent / Me₂BBr / CH₂Cl₂ / 2 h / -78 °C

With n-butyllithium; mercury(II) perchlorate; dimethylboron bromide; potassium hydride; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform;