5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine
CAS No.:890307-43-4
Molecular Formula:C₂₁H₂₇N₅O
Molecular Weight:365.478
Hs Code.:

Synonyms:5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

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Chemical Property of 5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

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Technology Process of 5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

There total 7 articles about 5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 890307-52-5
7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

: 124-40-3
dimethyl amine

: 890307-43-4
5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: 7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h;

dimethyl amine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 875769-58-7
(2,6-dichloro-3-nitropyridin-4-yl)-(2-ethyl-6-methylbenzyl)amine

: 890307-43-4
5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol; 2-methoxy-ethanol / 1 h / 55 °C

2.1: hydrogen / nickel / ethanol; water; N,N-dimethyl-formamide / 20 h / 40 °C / 750.08 Torr

3.1: hydrogenchloride / ethanol; water / 14 h / 20 °C / Heating / reflux

4.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 15 h / 140 °C / 15001.5 Torr

5.1: lithium hydroxide; water / 1,4-dioxane / 4 h / 85 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 12 h / 20 °C

6.2: 5 h / 20 °C

With hydrogenchloride; lithium hydroxide; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; nickel; In 1,4-dioxane; ethanol; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 200799-20-8
2-ethyl-6-methylbenzyl chloride

: 890307-43-4
5-(Dimethylaminocarbonyl)-7-(2-ethyl-6-methylbenzyl)amino-2,3-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

1.2: 2.5 h / 0 - 20 °C

2.1: triethylamine / ethanol; 2-methoxy-ethanol / 1 h / 55 °C

3.1: hydrogen / nickel / ethanol; water; N,N-dimethyl-formamide / 20 h / 40 °C / 750.08 Torr

4.1: hydrogenchloride / ethanol; water / 14 h / 20 °C / Heating / reflux

5.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 15 h / 140 °C / 15001.5 Torr

6.1: lithium hydroxide; water / 1,4-dioxane / 4 h / 85 °C

7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 12 h / 20 °C

7.2: 5 h / 20 °C

With hydrogenchloride; lithium hydroxide; water; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;