(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

Base Information

Chemical Name:(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate
CAS No.:1445591-71-8
Molecular Formula:C₁₈H₂₀BrNO₆
Molecular Weight:426.264
Hs Code.:

Synonyms:(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

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Chemical Property of (7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

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Technology Process of (7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

There total 4 articles about (7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1445591-69-4
(7,8-trans)-8-(methoxycarbonyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylic acid

: 5467-72-1
α-amino-4-bromoacetophenone hydrochloride

: 1445591-71-8
(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.0833333h;

Reference yield:

: 1445591-65-0,164916-54-5
(1,2-trans)-1-benzyl 2-methyl 4-oxocyclopentane-1,2-dicarboxylate

: 1445591-71-8
(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Dean-Stark; Reflux

2: hydrogen; palladium 10% on activated carbon / methanol

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 - 5 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 115694-82-1
(1S,2S)-2-(methoxycarbonyl)-4-oxocyclopentanecarboxylic acid

: 1445591-71-8
(7,8-trans)-methyl 8-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)-1,4-dioxaspiro[4.4]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / toluene / 0.67 h / 70 °C / Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 2 h / Dean-Stark; Reflux

3.1: hydrogen; palladium 10% on activated carbon / methanol

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 - 5 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide; toluene;