2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

Base Information

• Chemical Name: 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate
• CAS No.: 721918-21-4
• Molecular Formula: C₃₆H₃₃ClF₃NO₄Si
• Molecular Weight: 664.196
• Mol file: 721918-21-4.mol

Synonyms:2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

Chemical Property of 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

There total 3 articles about 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one (863225-72-3) + acetic anhydride (108-24-7) → 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate (721918-21-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate (721918-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 3 h / 20 °C

2: 6.82 g / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061093j

Reference yield:

4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinolinone (275375-69-4,722497-38-3,722497-39-4) → 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate (721918-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 3 h / 20 °C

2: 6.82 g / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061093j

upstream raw materials:

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one

acetic anhydride

tert-butylchlorodiphenylsilane

4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinolinone

Downstream raw materials:

2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

3-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(5-chloro-2-(2-methylallyloxy)phenyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

4-(3-allyl-5-chloro-2-hydroxyphenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

3-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(5-chloro-2-hydroxy-3-(2-methylallyl)phenyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one