4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

Base Information

• Chemical Name: 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one
• CAS No.: 930780-16-8
• Molecular Formula: C₃₈H₃₇ClF₃NO₃Si
• Molecular Weight: 676.25
• Mol file: 930780-16-8.mol

Synonyms:4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

Chemical Property of 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

There total 6 articles about 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H33ClF3NO3Si + allyl bromide (106-95-6) → 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one (930780-16-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 18h;

DOI:10.1021/jm061093j

Reference yield:

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one (863225-72-3) → 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one (930780-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 6.82 g / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: 79 percent / K₂CO₃ / acetone / 18 h / 20 °C

3: LiOH*H₂O / ethanol / 4 h / 20 °C

4: 0.24 g / potassium carbonate / acetone / 18 h / 20 °C

With lithium hydroxide; potassium carbonate; triethylamine; In ethanol; dichloromethane; acetone;

DOI:10.1021/jm061093j

Reference yield:

2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate (721918-21-4) → 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one (930780-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / acetone / 18 h / 20 °C

2: LiOH*H₂O / ethanol / 4 h / 20 °C

3: 0.24 g / potassium carbonate / acetone / 18 h / 20 °C

With lithium hydroxide; potassium carbonate; In ethanol; acetone;

DOI:10.1021/jm061093j

upstream raw materials:

allyl bromide

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one

2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate

Downstream raw materials:

4-(3-allyl-5-chloro-2-hydroxyphenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one

C₂₂H₁₉ClF₃NO₃

C₃₈H₃₉ClF₃NO₅Si

C₂₂H₂₁ClF₃NO₅