(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Base Information

Chemical Name:(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone
CAS No.:1464150-80-8
Molecular Formula:C₂₅H₂₄ClN₅O
Molecular Weight:445.951
Hs Code.:

Synonyms:(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Suppliers and Price of (4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

There total 6 articles about (4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 5308-25-8
4-ethylpiperazine

: 1464154-16-2
4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoic acid

: 1464150-80-8
(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Guidance literature:: 4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 3h;

4-ethylpiperazine; With potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 5308-25-8
4-ethylpiperazine

: 4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoic acid chloride

: 1464150-80-8
(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1464150-80-8
(4-(3-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-ethylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

3: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

4: potassium hydroxide / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium carbonate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;