2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

Base Information

Chemical Name:2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester
CAS No.:1332699-74-7
Molecular Formula:C₂₇H₃₀N₂O₅S
Molecular Weight:494.612
Hs Code.:

Synonyms:2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

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Chemical Property of 2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

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Technology Process of 2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

There total 11 articles about 2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1332699-73-6
4-benzenesulfinyl-2-(2-benzenesulfinylethyl)-2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}butyric acid methyl ester

: 1332699-74-7
2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

Guidance literature:: With pyridine; In para-xylene; at 140 ℃; for 3h; under 12929 Torr; Microwave irradiation; Inert atmosphere;
DOI:10.1021/ol201980r

Reference yield:

: 1332699-70-3
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

: 1332699-74-7
2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

4: pyridine / para-xylene / 3 h / 140 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; para-xylene; ethyl acetate;
DOI:10.1021/ol201980r

Reference yield:

: 1332699-71-4
2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethanol

: 1332699-74-7
2-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethylamino}-2-vinylbut-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

3: pyridine / para-xylene / 3 h / 140 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; para-xylene; ethyl acetate;
DOI:10.1021/ol201980r