6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

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Chemical Name:6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione
CAS No.:1383377-63-6
Molecular Formula:C₂₄H₁₇FN₄O₂
Molecular Weight:412.423
Hs Code.:

Synonyms:6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

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Chemical Property of 6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

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Technology Process of 6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

There total 8 articles about 6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1383377-53-4
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)furo[3,4-b]-pyridine-5,7-dione

: 100-46-9
benzylamine

: 1383377-63-6
6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

Guidance literature:: With acetic acid; for 18h; Reflux;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-63-6
6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 50 °C

3: potassium hydroxide; water / 24 h / 100 °C

4: acetic anhydride; acetic acid / 3 h / 110 °C

5: acetic acid / 18 h / Reflux

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; water; acetic anhydride; caesium carbonate; acetic acid; potassium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

: 1383377-63-6
6-benzyl-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5Hpyrrolo[3,4-b]pyridine-5,7(6H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 2 h / 50 °C

2: potassium hydroxide; water / 24 h / 100 °C

3: acetic anhydride; acetic acid / 3 h / 110 °C

4: acetic acid / 18 h / Reflux

With water; acetic anhydride; acetic acid; potassium hydroxide; In dimethyl sulfoxide;