(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

Base Information

Chemical Name:(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate
CAS No.:1361509-59-2
Molecular Formula:C₃₇H₃₈N₂O₄Se
Molecular Weight:653.68
Hs Code.:

Synonyms:(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

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Chemical Property of (S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

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Technology Process of (S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

There total 3 articles about (S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 103321-61-5
Fmoc-Phe-Leu-OBzl

: 1361509-59-2
(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

Guidance literature:: Fmoc-Phe-Leu-OBzl; With phosphorus pentachloride; N,N-dimethyl-formamide; In benzene; at 20 ℃; Inert atmosphere;

With selenium; lithium aluminium tetrahydride; In tetrahydrofuran; benzene; at 20 ℃; for 0.166667h; Inert atmosphere; Darkness;
DOI:10.1021/jo2024703

Reference yield:

: 1738-69-8
L-Leucine benzyl ester

: 1361509-59-2
(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: phosphorus pentachloride; N,N-dimethyl-formamide / benzene / 20 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere; Darkness

With phosphorus pentachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; benzene;
DOI:10.1021/jo2024703

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 1361509-59-2
(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: phosphorus pentachloride; N,N-dimethyl-formamide / benzene / 20 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere; Darkness

With phosphorus pentachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; benzene;
DOI:10.1021/jo2024703