(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1361509-92-3
Molecular Formula:C₄₂H₄₅N₃O₅Se
Molecular Weight:750.796
Hs Code.:

(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

There total 5 articles about (S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₈N₂O₂Se

: 71989-31-6
Fmoc-Pro-OH

: 1361509-92-3
(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo2024703

Reference yield:

: 103321-61-5
Fmoc-Phe-Leu-OBzl

: 1361509-92-3
(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus pentachloride; N,N-dimethyl-formamide / benzene / 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere; Darkness

2.1: diethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With phosphorus pentachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo2024703

Reference yield:

: 1361509-59-2
(S)-benzyl 2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropaneselenoamido)-4-methylpentanoate

: 1361509-92-3
(S)-(9H-fluoren-9-yl)methyl 2-((S)-1-((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-ylamino)-3-phenyl-1-selenoxopropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo2024703