Technology Process of 6-chloro-7-(3-cyanophenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine-8-carboxamide
There total 15 articles about 6-chloro-7-(3-cyanophenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine-8-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 8-carbamoyl-6-chloro-7-(3-cyanophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate;
With
trifluoroacetic acid;
In
Difluoromethane;
at 20 ℃;
for 1h;
With
ammonium hydroxide;
In
water;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrahydrofuran / 2 h / 20 - 25 °C
2.1: N-chloro-succinimide / tetrahydrofuran / 6 h / Reflux
3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile
3.2: 6 h / Reflux
4.1: hydrogenchloride / water; methanol / 2 h / 60 °C
5.1: hydrogenchloride / water; methanol / 4 h / 90 °C
6.1: dichloromethane / 1 h / 20 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C
8.1: tetrahydrofuran / 2 h / 60 °C
9.1: ammonium hydroxide / N,N-dimethyl-formamide; water / 3 h / 110 °C
10.1: trifluoroacetic acid / Difluoromethane / 1 h / 20 °C
With
hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; water; trifluoroacetic acid; sodium hydroxide; lithium hydroxide;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N-chloro-succinimide / tetrahydrofuran / 6 h / Reflux
2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile
2.2: 6 h / Reflux
3.1: hydrogenchloride / water; methanol / 2 h / 60 °C
4.1: hydrogenchloride / water; methanol / 4 h / 90 °C
5.1: dichloromethane / 1 h / 20 °C
6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C
7.1: tetrahydrofuran / 2 h / 60 °C
8.1: ammonium hydroxide / N,N-dimethyl-formamide; water / 3 h / 110 °C
9.1: trifluoroacetic acid / Difluoromethane / 1 h / 20 °C
With
hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; water; trifluoroacetic acid; sodium hydroxide; lithium hydroxide;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;