3-(3-CYANO-PHENYL)-ACRYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-(3-CYANO-PHENYL)-ACRYLIC ACID METHYL ESTER
• CAS No.: 193151-10-9
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Mol file: 193151-10-9.mol

Synonyms:methyl 3-(3-cyanophenyl)-acrylate;(E)-3-(3-cyanophenyl)acrylic acid methyl ester;(E)-methyl 3-(3-cyanophenyl)acrylate;methyl (E)-3-(3-cyanophenyl)acrylate;methyl (E)-3-(3-cyanophenyl)prop-2-enoate;methyl trans-3-cyanocinnamate;

Chemical Property of 3-(3-CYANO-PHENYL)-ACRYLIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 321.3±25.0 °C(Predicted)
• PSA: 50.09000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 1.74448

Purity/Quality:

97% ^*data from raw suppliers

(E)-Methyl3-(3-cyanophenyl)acrylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-CYANO-PHENYL)-ACRYLIC ACID METHYL ESTER

There total 12 articles about 3-(3-CYANO-PHENYL)-ACRYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-iodobenzonitrile (69113-59-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-(3-cyano-phenyl)-acrylic acid methyl ester (193151-10-9)

Guidance literature:

With triethylamine; In acetonitrile; at 100 ℃; for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1007/s10562-021-03914-z

Reference yield: 94.0%

3-cyanobromobenzene (6952-59-6) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-(3-cyano-phenyl)-acrylic acid methyl ester (193151-10-9)

Guidance literature:

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); N-Methyldicyclohexylamine; 4,4'-di-tert-butylbiphenyl; tetrabutyl-ammonium chloride; In N,N-dimethyl acetamide; at 80 ℃; for 24h; Glovebox;

DOI:10.1021/op300364p

Reference yield: 93.0%

trimethyl phosphonoacetate (5927-18-4) + 3-Cyanobenzaldehyde (24964-64-5) → 3-(3-cyano-phenyl)-acrylic acid methyl ester (193151-10-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

upstream raw materials:

3-Cyanobenzaldehyde

(methyloxycarbonylmethyl)triphenylphosphonium bromide

methanol

(3E)-3-(3-cyanophenyl)acrylic acid

Downstream raw materials:

3-[(E)-3-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-oxo-propenyl]-benzonitrile

3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile

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