3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

Base Information

Chemical Name:3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide
CAS No.:142731-51-9
Molecular Formula:C₁₆H₂₀FN₃O₂
Molecular Weight:305.352
Hs Code.:

Synonyms:3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

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Chemical Property of 3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

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Technology Process of 3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

There total 4 articles about 3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 142731-45-1
2-[3-(4-fluorophenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetic acid

: 75-64-9
tert-butylamine

: 142731-51-9
3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield:

: 142731-42-8
3-(4-fluorophenyl)-5,6-dihydro-6-oxo-1(4H)-pyridazineacetic acid methyl ester

: 142731-51-9
3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aqueous LiOH / methanol / Ambient temperature

2: 30 percent / N(C₂H₅)3, diethyl cyanophosphonate / dimethylformamide / 3 h / 0 °C

With lithium hydroxide; diethyl cyanophosphonate; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 366-77-8
4-(4-fluorophenyl)-4-oxopropionic acid

: 142731-51-9
3-(4-fluorophenyl)-5,6-dihydro-N-(1,1-dimethylethyl)-6-oxo-1(4H)-pyridazineacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / hydrazine hydrate / ethanol / 17 h / Heating

2: 1) NaH / 1) THF, room temp., 30 min; 2) THF, room temp., 17 h

3: 90 percent / aqueous LiOH / methanol / Ambient temperature

4: 30 percent / N(C₂H₅)3, diethyl cyanophosphonate / dimethylformamide / 3 h / 0 °C

With lithium hydroxide; diethyl cyanophosphonate; sodium hydride; hydrazine hydrate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;