(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

Base Information

Chemical Name:(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene
CAS No.:139377-25-6
Molecular Formula:C₁₉H₁₈ClNO₃
Molecular Weight:343.81
Hs Code.:

Synonyms:(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

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Technology Process of (4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

There total 3 articles about (4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 77943-39-6
4-methyl-5-phenyloxazolidin-2-one

: 52085-96-8
3-(4-chlorophenyl)propanoyl chloride

: 139377-25-6
(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

Guidance literature:: With n-butyllithium; In hexane; at -78 - 20 ℃; for 1h;

Reference yield:

: 2019-34-3
3-(4-chlorophenyl)propanoic acid

: 139377-25-6
(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / a) -78 deg C, 10 min, b) 0 deg C, 30 min

2: 1) n-BuLi / 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min

With n-butyllithium; triethylamine; In tetrahydrofuran;
DOI:10.1021/jo00032a028

Reference yield:

: 77943-39-6
4-methyl-5-phenyloxazolidin-2-one

: 1027659-22-8
C₁₄H₁₇ClO₃

: 139377-25-6
(4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min;
DOI:10.1021/jo00032a028